Side effects of ORLADEYO® have been studied in multiple clinical studies over several years

In the first 6 months of the clinical study (part 1)

  • The most commona side effects were abdominal pain, vomiting, diarrhea, back pain, and heartburn. These are not all of the possible side effects of ORLADEYO. For more information, ask your healthcare provider or pharmacist
  • Not everyone experienced gastrointestinal (GI) side effects. For those who did, they generally occurred early after starting treatment, became less frequent with time, and typically got better on their own

  • No one being treated with ORLADEYO 150 mg discontinued therapy due to GI side effects
  • One person being treated with ORLADEYO 110 mg discontinued. If you experience GI side effects that don’t go away, your healthcare provider may prescribe a reduced dosage of ORLADEYO (110 mg, once daily with food)

No new types of side effects were seen in those who continued ORLADEYO for 2 years.

Another clinical study of 227 people looked at the safety of ORLADEYO and found results that support the findings from the previous study.

aSide effects that occurred in at least 10% of people taking ORLADEYO and more frequently than in those taking placebo.

What to avoid when taking ORLADEYO

  • Do not take ORLADEYO to treat an acute swelling attack; it is not known if ORLADEYO is safe or effective in treating acute attacks
  • Do not take additional doses of ORLADEYO to treat an acute swelling attack
  • Do not take more than 1 capsule of ORLADEYO per day because extra doses can cause heart rhythm problems. If you do, call your healthcare provider right away
  • Do not start taking ORLADEYO without telling your healthcare provider about all the medicines you take. Taking ORLADEYO with certain other medicines may affect the way those medicines work and other medicines may affect how ORLADEYO works

Don’t forget to give your body time to adjust to new medication—even if you were on a previous preventative therapy.