Empower Patient Services

With Empower Patient Services, you come first

You will always have a dedicated team of real people to support you throughout your ORLADEYO® journey.

One stop for all of your ORLADEYO needs

Your dedicated team is here every step of the way, including:

Getting started on ORLADEYO

A team of experts will manage the insurance process
Help exploring financial support options regardless of insurance status
Financial assistance available for eligible patients
$0 copay if you are commercially insured, up to the annual program maximum^a
Quick Start shipment of ORLADEYO to minimize delays or disruptions in accessing treatment for eligible patients^b
On average, patients receive their first shipment of ORLADEYO in less than a week after their prescription has been received

Shipments your way

Coordinate your shipment through proactive phone calls from your team or on your time with the ORLADEYO Empower Patient Services portal
The power to choose when and where you receive your shipment of ORLADEYO

Personalized support

Customized communications
A dedicated team of pharmacists available 24/7
Resources to support your needs

^aSubject to terms and conditions of the Co-pay Assistance Program, which you can obtain from your Empower Patient Services team. Not valid for prescriptions eligible to be reimbursed, in whole or in part, by federal or state programs (including any federal or state prescription drug assistance programs). BioCryst reserves the right to rescind, revoke, or amend the program at any time without notice.

^bSubject to terms and conditions of the Quick Start program. BioCryst reserves the right to rescind, revoke, or amend the program.

Meet your support team

— Michelle, patient support manager

Meet the Empower Patient Services team.

We are your Empower Patient Services primary point of contact for ORLADEYO. We‘re here to answer questions, provide resources, help manage the insurance process, and share timely updates. We streamline communication by working on your behalf with the rest of the Empower Patient Services team, including your healthcare provider.

We‘re the friendly voice answering telephone calls directed to our Empower Patient Services main line and proactively calling you to coordinate your next shipment of ORLADEYO. We process the paperwork and work with your healthcare provider to ensure we have an accurate and complete start form so you can quickly start treatment.

We work directly with your insurance company to investigate your benefits and identify the best path forward for your access to ORLADEYO. We partner with your healthcare provider and work on your behalf to remove barriers to treatment.

We‘re dedicated to obtaining approval from your insurance company for the treatment you and your healthcare provider have decided is right for you. We partner with your healthcare provider and work directly with your health insurance to initiate appeals for denied claims or authorizations.

We offer in-depth initial counseling to further support treatment transition instructions from your healthcare provider and share tips to help with side effects while your body adjusts. We monitor how you are managing your diagnosis and taking your medication, and we keep in touch with your healthcare provider to make sure things are going smoothly. We‘re available 24/7 to field any medical questions about ORLADEYO.

Give us a call at 1-866-5-EMPOWER (1-866-536-7693) to learn
more about how we can help YOU.

Hear patient and prescriber experiences with Empower Patient Services.

Learn more

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS ORLADEYO® (berotralstat)?

It is not known if ORLADEYO is safe and effective to treat an acute HAE attack, therefore ORLADEYO should not be used to treat an acute HAE attack.

Do not take more than one capsule of ORLADEYO per day because extra doses can cause heart rhythm problems.

IMPORTANT SAFETY INFORMATION

Before taking ORLADEYO, tell your healthcare provider about all of your medical conditions, including if you

have liver problems or are on kidney dialysis.

are pregnant or planning to become pregnant. It is not known if ORLADEYO can harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if ORLADEYO passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking ORLADEYO.

Tell your healthcare provider about all of the medicines you take, including other medicines for HAE, prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ORLADEYO with certain other medicines may affect the way other medicines work and other medicines may affect how ORLADEYO works.

Know the medicines you take and keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ORLADEYO?

Taking more than one capsule of ORLADEYO per day may cause serious side effects, including heart rhythm problems. A heart rhythm problem called QT prolongation can happen in people who take more than one capsule of ORLADEYO per day. This condition can cause an abnormal heartbeat. Do not take more than one capsule of ORLADEYO per day.

The most common side effects of ORLADEYO include abdominal pain, vomiting, diarrhea, back pain, and heartburn. These are not all of the possible side effects of ORLADEYO. For more information, ask your healthcare provider or pharmacist.

Talk to your healthcare provider for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to BioCryst Pharmaceuticals, Inc at 1-833-633-2279 or to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

WHAT IS ORLADEYO® (berotralstat)?

ORLADEYO (or-luh-DAY-oh) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in adults and children 12 years of age and older. It is not known if ORLADEYO is safe and effective in children under 12 years of age. It is not known if ORLADEYO is safe and effective to treat an acute HAE attack, therefore ORLADEYO should not be used to treat an acute HAE attack.