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This year’s hae day :-) theme has inspired us to take action and activate the HAE community by spreading words of encouragement

This year’s hae day :-) theme has inspired us to take action and activate the HAE community by spreading words of encouragement — and we need your help. Find out how you can get involved.

Here to help: BioCryst recognizes the unique challenges brought upon by the COVID-19 pandemic,

Here to help: BioCryst recognizes the unique challenges brought upon by the COVID-19 pandemic, which is why we’re committed to maintaining the accessibility of ORLADEYOTM (berotralstat) in a safe manner for appropriate patients. If you are prescribed ORLADEYO or are interested in learning more about it, please reach out to Empower Patient Services at 1-866-5-EMPOWER (1-866-536-7693) with questions.

This website is intended for US residents only.

  • Important Safety Information
  • Prescribing Information
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Orladeyo Patient
  • Living with HAE
    • HAE and how it’s treated
    • Why preventative therapy?
    • Choose the right therapy for you
  • Why ORLADEYO?
    • Oral administration
    • How ORLADEYO works
    • Preventing HAE attacks
    • Potential side effects
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    • Get started with ORLADEYO
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Sign up to receive daily text reminders to take your ORLADEYOTM (berotralstat)

Mobile Terms of Use

By agreeing to the ORLADEYO™ (berotralstat) text message reminder service (“Program”) Terms of Use, you consent to receive autodialed text messages on the mobile device number you have provided subject to the Terms of Use described below. You understand that this consent is not a condition of purchase or use of ORLADEYO or of any BioCryst US Sales Co., LLC (including its affiliates, “BioCryst”) product or service.

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  • You agree that you are at least 18 years of age or older; or, if you are not at least 18 years old, you have your parent or guardian’s permission to use the Program, and your parent or guardian has read and agrees to this Terms of Use on your behalf
  • You agree that all registration information you submitted is accurate and truthful, including your mobile device number
  • If you change your mobile device number, you agree to promptly contact us at [email protected] so we can update our records and avoid having text messages inadvertently sent to an unintended recipient
  • Once enrolled in the Program, participants will receive approximately 30 text messages each month
  • There is no fee payable to BioCryst to receive text messages; however, your carrier’s message and data rates may apply
  • You are responsible for remembering to take ORLADEYO and all medication. The Program may not send messages every day and you release BioCryst from any liability resulting from your failure to take ORLADEYO in accordance with your doctors’ instructions
  • Data obtained from you in connection with your registration for, and use of, this Program may include your mobile device number and/or email address and related carrier information, and will be used to provide dosing reminders and relevant updates and alerts. You may also receive additional educational, marketing communications, and promotional information about BioCryst, Empower Patient Services, ORLADEYO, and/or HAE. For more information, please see our Privacy Policy. The information collected as part of this Program is not sold to third parties
  • BioCryst is not liable for any delays in the receipt of any SMS messages
  • While BioCryst cannot guarantee the Program is compatible with your mobile device carrier, this Program is valid with most major US carriers, including Verizon Wireless, Sprint, Nextel, Boost, T-Mobile, AT&T, Alltel, ACS Wireless, Bluegrass Cellular, Carolina West Wireless, CellCom, Cellular One of East Central Illinois, Cincinnati Bell, Cricket, C Spire Wireless, Duet IP (AKA Max/Benton/Albany), Element Mobile, Epic Touch, GCI Communications, Golden State, Hawkeye (Chat Mobility), Hawkeye (NW Missouri Cellular), Illinois Valley Cellular, Inland Cellular, iWireless, Keystone Wireless (Immix/PC Management), Metro, Mobi PCS, Mosaic, MTPCS/Cellular One (Cellone Nation), Nex-Tech Wireless, Panhandle Telecommunication, Pioneer, Plateau, Revol Wireless, Rina-Custer, Rina-All West, Rina-Cambridge Telecom Coop, Rina-Eagle Valley Comm, Rina-Farmers Mutual Telephone Co, Rina-Nucla Nutria Telephone Co, Rina-Silver Star, Rina-South Central Comm, Rina-Syringa, Rina-UBET, Rina-Manti, Simmetry, South Canaan/Cellular One of NEPA, Thumb Cellular, Union Wireless, United Wireless, US Cellular, Viaero Wireless, Virgin Mobile, West Central Wireless (includes Five Star Wireless)
  • You are responsible for obtaining and maintaining any equipment (such as an SMS-equipped mobile device) or ancillary services (such as SMS-equipped mobile service) needed to connect to, access, or otherwise use the Program and that such equipment and services are compatible with the Program
  • Responses to the platform are not monitored and responses will not be received
  • If you experience a medical emergency, call your local emergency services immediately
  • BioCryst reserves the right to rescind, revoke, or amend text message reminders without notice at any time and for any reason
  • You can unsubscribe at any time by texting S to STOP or UNSUBSCRIBE in response to a text message
  • Contact your healthcare provider for medical advice
  • For questions about ORLADEYO text message reminders, review our frequently asked questions
  • For questions about ORLADEYO, please contact your healthcare provider or an Empower Patient Services care coordinator at 1-866-5-EMPOWER (1-866-536-7693)
  • The Program is intended as a helpful reminder but does not constitute medical advice
  • You agree that the Program, including the content of the messages sent to you by it, are the property of BioCryst and that you will not use the Program (or share content included therein) in any manner that infringes or violates the intellectual property rights of BioCryst or any third party or that violates the security of any computer or mobile network
  • The Program may contain links to third-party websites, products, or services that are not owned or controlled by BioCryst and when you access such third-party websites, products, or services, you acknowledge that you do so at your own risk
  • The Program is offered AS IS WITHOUT ANY WARRANTY OR CONDITION OF ANY KIND, EITHER EXPRESS OR IMPLIED, FROM REMIND OR ANYONE ELSE. THE SERVICES, CONTENT, AND ANY SOFTWARE ARE PROVIDED ON AN “AS IS” BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, MERCHANTABLE QUALITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT, OR THAT USE OF THE SERVICES WILL BE UNINTERRUPTED OR ERROR-FREE. SOME JURISDICTIONS DO NOT ALLOW LIMITATIONS ON HOW LONG AN IMPLIED WARRANTY LASTS, SO THE ABOVE LIMITATIONS MAY NOT APPLY TO YOU

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ORLADEYO™ (berotralstat) works to prevent attacks

ORLADEYO prevents hereditary angioedema (HAE) attacks by decreasing the activity of the protein kallikrein

How ORLADEYO™ works to prevent HAE attacks How ORLADEYO™ works to prevent HAE attacks
See how ORLADEYO can help to prevent HAE attacks

WHAT IS ORLADEYO™ (berotralstat)?

ORLADEYO (or-luh-DAY-oh) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in adults and children 12 years of age and older. It is not known if ORLADEYO is safe and effective in children under 12 years of age.

It is not known if ORLADEYO is safe and effective to treat an acute HAE attack, therefore ORLADEYO should not be used to treat an acute HAE attack.

Do not take more than one capsule of ORLADEYO per day because extra doses can cause heart rhythm problems.

IMPORTANT SAFETY INFORMATION

Before taking ORLADEYO, tell your healthcare provider about all of your medical conditions, including if you

  • have liver problems or are on kidney dialysis.
  • are pregnant or planning to become pregnant. It is not known if ORLADEYO can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ORLADEYO passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking ORLADEYO.

Tell your healthcare provider about all of the medicines you take, including other medicines for HAE, prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ORLADEYO with certain other medicines may affect the way other medicines work and other medicines may affect how ORLADEYO works.

Know the medicines you take and keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ORLADEYO?
Taking more than one capsule of ORLADEYO per day may cause serious side effects, including heart rhythm problems. A heart rhythm problem called QT prolongation can happen in people who take more than one capsule of ORLADEYO per day. This condition can cause an abnormal heartbeat. Do not take more than one capsule of ORLADEYO per day.

The most common side effects of ORLADEYO include abdominal pain, vomiting, diarrhea, back pain, and heartburn. These are not all of the possible side effects of ORLADEYO. For more information, ask your healthcare provider or pharmacist.

Talk to your healthcare provider for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to BioCryst Pharmaceuticals, Inc at 1-833-633-2279 or to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

For more information, please see the full Prescribing Information including the Patient Information.

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ORLADEYO is a trademark of BioCryst Pharmaceuticals, Inc.
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INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS ORLADEYO™ (berotralstat)?

ORLADEYO (or-luh-DAY-oh) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in adults and children 12 years of age and older. It is not known if ORLADEYO is safe and effective in children under 12 years of age.

It is not known if ORLADEYO is safe and effective to treat an acute HAE attack, therefore ORLADEYO should not be used to treat an acute HAE attack.

Do not take more than one capsule of ORLADEYO per day because extra doses can cause heart rhythm problems.

IMPORTANT SAFETY INFORMATION

Before taking ORLADEYO, tell your healthcare provider about all of your medical conditions, including if you

  • have liver problems or are on kidney dialysis.
  • are pregnant or planning to become pregnant. It is not known if ORLADEYO can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ORLADEYO passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking ORLADEYO.

Tell your healthcare provider about all of the medicines you take, including other medicines for HAE, prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ORLADEYO with certain other medicines may affect the way other medicines work and other medicines may affect how ORLADEYO works.

Know the medicines you take and keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ORLADEYO?
Taking more than one capsule of ORLADEYO per day may cause serious side effects, including heart rhythm problems. A heart rhythm problem called QT prolongation can happen in people who take more than one capsule of ORLADEYO per day. This condition can cause an abnormal heartbeat. Do not take more than one capsule of ORLADEYO per day.

The most common side effects of ORLADEYO include abdominal pain, vomiting, diarrhea, back pain, and heartburn. These are not all of the possible side effects of ORLADEYO. For more information, ask your healthcare provider or pharmacist.

Talk to your healthcare provider for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to BioCryst Pharmaceuticals, Inc at 1-833-633-2279 or to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

For more information, please see the full Prescribing Information including the Patient Information.

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